Salk Institute

Hunter Lab

Publications

Publications 1981 - 1990

Hunter, T., Sefton, B. M., and Cooper, J. A. 1981. Phosphorylation of tyrosine: its importance in viral transformation and normal cell metabolism. In Cold Spring Harbor Conferences on Cell Proliferation Vol. 8, "Protein Phosphorylation" (O. Rosen and E. G. Krebs, eds), pp. 1189-1202.

Sefton, B. M., Hunter, T., and Raschke, W. C. 1981. Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. Proc. Natl. Acad. Sci. USA 78:1552-1556.

Cooper, J. A., and Hunter, T. 1981. Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells. Mol. Cell. Biol. 1:165-178.

Cooper, J. A., and Hunter, T. 1981. Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins. Mol. Cell. Biol. 1:394-407.

Sefton, B. M., Hunter, T., Ball, E. H., and Singer, S. J. 1981. Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell 24:165-174.

Adkins, B., and Hunter, T. 1981. Identification of a packaged cellular mRNA in virions of Rous sarcoma virus. J. Virol. 39: 471-480.

Adkins, B., Hunter, T., and Beemon, K. 1981. Expression of the PRCII avian sarcoma virus genome. J. Virol. 41:767-780.

Hunter, T., and Cooper, J. A. 1981. Epidermal growth factor induces rapid tyrosine phosphorylation in A431 human tumor cells. Cell 24:741-752.

Cooper, J. A., and Hunter, T. 1981. Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus. J. Cell Biol. 91:878-883.

Ali, I. U., and Hunter, T. 1981. Structural comparison of fibronectins from normal and transformed cells. J. Biol. Chem. 256:7671-7677.

Sefton, B. M., Hunter, T., Nigg, E. A., Singer, S. J., and Walter, G. 1981. Cytoskeletal targets for viral transforming proteins with tyrosine protein kinase activity. Cold Spring Harbor Symp. Quant. Biol. 46:939-951.

Papkoff, J., Lai, M. H.-T., Hunter, T., and Verma, I. M. 1981. Analysis of transforming gene products from Moloney murine sarcoma virus. Cell 27:109-119.

Walter, G., Hutchinson, M. A., Hunter, T., and Eckhart, W. 1981. Antibodies specific for the polyoma virus middle-size tumor antigen. Proc. Natl. Acad. Sci. USA 78:4882-4886.

Hunter, T., and Sefton, B. M. 1982. Protein kinases and viral transformation. In Molecular Aspects of Cellular Regulation Vol. 2 " Molecular Actions of Toxins and Viruses" (P. Cohen and S. Van Heyningen, eds), pp. 333-366, Elsevier/North Holland, Amsterdam.

Patschinsky, T., Hunter, T., Esch, F. S., Cooper, J. A., and Sefton, B. M. 1982. Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA 79:973-977.

Sefton, B. M., Patschinsky, T., Berdot, C., Hunter, T., and Elliott, T. 1982. The phosphorylation and metabolism of the transforming protein of Rous sarcoma virus. J. Virol. 41:813-820.

Nigg, E. A., Sefton, B. M., Hunter, T., Walter, G., and Singer, S. J. 1982. Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide. Proc. Natl. Acad. Sci. USA 79:5322-5326.

Cooper, J. A., and Hunter, T. 1982. Discrete primary locations of a tyrosine protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts. J. Cell Biol. 94:287-296.

Adkins, B., and Hunter, T. 1982. Two structurally and functionally different forms of the transforming protein of PRCII avian sarcoma virus. Mol. Cell. Biol. 2:890-896.

Adkins, B., Hunter, T., and Sefton, B. M. 1982. The transforming proteins of PRCII virus and Rous sarcoma virus form a complex with the same two cellular phosphoproteins. J. Virol. 43:448-455.

Cooper, J. A., Bowen-Pope, D. F., Raines, E., Ross, R., and Hunter, T. 1982. Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. Cell 31:263-273.

Hunter, T. 1982. Synthetic peptide substrates for a tyrosine protein kinase. J. Biol. Chem. 257:4843-4848.

Hunter, T. 1982. Phosphotyrosine - a new protein modification. Trends Biochem. Sci. 7:246-249.

Donoghue, D. J., and Hunter, T. 1982. Expression of transforming region of Moloney murine sarcoma virus in Escherichia coli as a fusion protein with small tumor antigen of polyoma virus. Proc. Natl. Acad. Sci. USA 79:800-804.

Donoghue, D. J., and Hunter, T. 1982. A generalized method of subcloning DNA fragments by restriction site reconstruction: application to sequencing the amino-terminal coding region of the transforming gene of Gazdar murine sarcoma virus. Nucleic Acids Res. 10:2549-2564.

Papkoff, J., Verma, I. M., and Hunter, T. 1982. Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus. Cell 29:417-426.

Papkoff, J., and Hunter, T. 1982. Identification of proteins encoded by the Gazdar murine sarcoma virus genome by in vitro translation and comparison to Moloney murine sarcoma virus 124. J. Virol. 43:533-543.

Papkoff, J., Lai, M. H.-T., and Hunter, T. 1982. Analysis of v‑mos encoded proteins in cells transformed by several related murine sarcoma viruses. J. Cell. Biochem. 19:349-362; 1983. In UCLA Symposia on Differentiation" (E. M. Scolnick and A. J. Levine, eds), pp. 121-134, Alan R. Liss, Inc., New York.

Walter, G., Hutchinson, M. A., Hunter, T., and Eckhart, W. 1982. Purification of polyoma virus medium-size tumor antigen by immunoaffinity chromatography. Proc. Natl. Acad. Sci. USA 79:4025-4029.

Cooper, J. A., and Hunter, T. 1983. Analysis of substrates for tyrosine protein kinases. In UCLA Symposia on Molecular and Cellular Biology New Series Vol. 5, "Tumor Viruses and Differentiation" (E. Scolnick and A. J. Levine, eds), pp. 411-420, Alan R. Liss, Inc., New York.

Hunter, T., and Cooper, J. A. 1983. A comparison of the tyrosine protein kinases encoded by retroviruses and activated by growth factors. In UCLA Symposia on Molecular and Cellular Biology New Series Vol. 6, "Evolution of Hormone-Receptor Systems" (R. A. Bradshaw and G. N. Gill, eds), pp. 369-382, Alan R. Liss, Inc., New York.

Cooper, J., Nakamura, K. D., Hunter, T., and Weber, M. J. 1983. Phosphotyrosine-containing proteins and expression of transformation parameters in cells infected with partial transformation mutants of Rous sarcoma virus. J. Virol. 46:15-28.

Cooper, J. A., and Hunter, T. 1983. Identification and characterization of cellular targets for tyrosine protein kinases. J. Biol. Chem. 258:1108-1115.

Sefton, B. M., Hunter, T., and Cooper, J. 1983. Some lymphoid cell lines transformed by Abelson murine leukemia virus lack a major 36,000-dalton tyrosine protein kinase substrate. Mol. Cell. Biol. 3:56-63.

Nigg, E. A., Cooper, J. A., and Hunter, T. 1983. Immunofluorescent localization of a 39,000 dalton substrate of tyrosine protein kinases to the cytoplasmic face of the plasma membrane. J. Cell Biol. 96:1601-1609.

Cooper, J. A., Reiss, N. A., Schwartz, R. J., and Hunter, T. 1983. Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus. Nature 302:218-223.

Hunter, T., and Cooper, J. A. 1983. The role of phosphorylation in malignant transformation by viruses and in cellular growth control. Prog. Nucl. Acid Res. Mol. Biol. 29:221-232.

Cooper, J. A., Sefton, B. M., and Hunter, T. 1983. Detection and quantification of phosphotyrosine in proteins. Meth. Enzymol. 99:387-402.

Cooper, J. A., Scolnick, E. M., Ozanne, B., and Hunter, T. 1983. Epidermal growth factor receptor metabolism in human A431 cells infected with Snyder-Theilen feline sarcoma virus or Harvey or Kirsten murine sarcoma virus. J. Virol. 48:752-764.

Hunter, T., and Cooper, J. A. 1983. Is tyrosine phosphorylation involved in growth control? Cell Biol. Internat. Reports 7: 505-506.

Cooper, J. A., and Hunter, T. 1983. Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins. Current Topics in Microbiol. Immunol. 107:125-161.

Papkoff, J., and Hunter, T. 1983. Detection of an 85,000-dalton phosphoprotein in ts110 murine sarcoma virus-infected cells with antiserum against a v‑mos peptide. J. Virol. 45:1177-1182.

Papkoff, J., Nigg, E. A., and Hunter, T. 1983. The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein. Cell 33:161-172.

Donoghue, D. J., and Hunter, T. 1983. The recombinational junctions of variants of Moloney murine sarcoma virus: the generation and divergence of a mammalian transforming gene. J. Virol. 45:607-617.

Hunter, T., Jackson, R., and Zimmern, D. 1983. Multiple proteins and subgenomic mRNAs may be derived from a single open reading frame on tobacco mosaic virus RNA. Nucleic Acids. Res. 11:801-821.

Zimmern, D., and Hunter, T. 1983. Point mutation in the 30-K open reading frame of TMV implicated in temperature-sensitive assembly and local lesion spreading of mutant Ni 2519. EMBO J. 2:1893-1900.

Kiberstis, P. A., Pessi, A., Atherton, E., Jackson, R., Hunter, T., and Zimmern, D. 1983. Analysis of in vitro and in vivo products of the TMV 30kDa open reading frame using antisera against a synthetic peptide. FEBS Lett. 164:355-360.

Gould, K. L., Cooper, J. A., and Hunter, T. 1984. The 46,000-dalton tyrosine protein kinase substrate is widespread, whereas the 36,000-dalton substrate is only expressed at high levels in certain rodent tissues. J. Cell Biol. 98:487-497.

Cooper, J. A., Esch, F. S., Taylor, S. S., and Hunter, T. l984. Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J. Biol. Chem. 259:7835-7841.

Cooper, J. A., Sefton, B. M., and Hunter, T. 1984. Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. Mol. Cell. Biol. 4:30-37.

Hunter, T., and Cooper, J. A. 1984. Rapid tyrosine phosphorylation of a 42,000-dalton protein is a common response to many mitogens. Cancer Cells Vol. 2 (A. J. Levine, W. C. Topp, G. Vande Woude and J. D. Watson, eds), Oncogenes and Viral Genes pp. 61-68, Cold Spring Harbor Laboratory.

Cochet, C., Gill, G. N., Meisenhelder, J., Cooper, J. A., and Hunter, T. 1984. C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. J. Biol. Chem. 259:2553-2558.

Hunter, T., and Cooper, J. A. 1984. Tyrosine protein kinases and their substrates: an overview. Advances in Cyclic Nucleotide and Protein Phosphorylation Research 17:443-455.

Sefton, B. M., and Hunter, T. l984. Tyrosine protein kinases. Advances in Cyclic Nucleotide and Protein Phosphorylation Research 18:195-226.

Hunter, T., Gould, K., and Cooper, J. A. 1984. Tyrosine protein kinases, viral transformation and the control of cell proliferation. Biochem. Soc. Transact. 12:757-759.

Hunter, T. 1984. The proteins of oncogenes. Scientific American 250, Vol. 8, pp. 70-79.

Hunter, T. l984. Oncogenes and proto-oncogenes: how do they differ? J. Natl. Cancer Inst. 73:773-786.

Cooper, J. A., Gould, K., and Hunter, T. l984. Phosphorylation at tyrosine in normal and transformed cells. In RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS (P. Furmanski, J. C. Hager and M. A. Rich, eds), pp. 41-53, Martinus Nijhoff Publishing, Boston.

Hunter, T., Ling, N., and Cooper, J. A. l984. Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature 311:480-483.

Hunter, T. 1984. The epidermal growth factor receptor gene and its product. Nature 311:414-416.

Voronova, A. F., Buss, J. E., Patschinsky, T., Hunter, T., and Sefton, B. M. l984. Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells. Mol. Cell. Biol. 4:2705-2713.

Kruijer, W., Cooper, J. A., Hunter, T., and Verma, I. M. 1984. Platelet-derived growth factor induces rapid but transient expression of the c‑fos gene and protein. Nature 312:711-716.

Hunter, T., Hutchinson, M. A., and Eckhart, W. 1984. Polyoma middle-sized T antigen can be phosphorylated on tyrosine at multiple sites in vitro. EMBO J. 3:73-79.

Donoghue, D. J., Anderson, C., Hunter, T., and Kaplan, P. L. 1984. Transmission of the polyoma virus middle T gene as the oncogene of a murine retrovirus. Nature 308:748-750.

Cooper, J. A., Hunter, T., and Shalloway, D. 1985. Protein-tyrosine kinase activity of pp60c‑src is restricted in intact cells. In Cancer Cells Vol. 3, Growth Factors and Transformation (J. Feramisco, B. Ozanne and C. Stiles, eds) pp. 321-328, Cold Spring Harbor Laboratory.

Verma, I. M., Mitchell, R. L., Kruijer, W., Van Beveren, C., Zokas, L., Hunter, T., and Cooper, J. A. 1985. Proto-oncogene fos: induction and regulation during growth and differentiation. In Cancer Cells Vol. 3, Growth Factors and Transformation (J. Feramisco, B. Ozanne and C. Stiles, eds) pp. 275-287, Cold Spring Harbor Laboratory.

Hunter, T., and Cooper, J. A. 1985. Protein-tyrosine kinases. Annu. Rev. Biochem. 54:897-930.

Hunter, T. 1985. The functions of oncogene products. In Cell Transformation (J. Celis and A. Graessmann, eds), NATO ASI Series A: Life Sciences Vol. 94, pp. 79-95, Plenum Publishing Corporation, New York.

Hunter, T., Alexander, C. B., and Cooper, J. A. 1985. Protein phosphorylation and growth control. In CIBA Symposium 116, Growth factors in biology and medicine, pp. 188-204, Pitman Publishing, London.

Hunter, T. 1985. Oncogenes and growth control. Trends Biochem. Sci. 10:275-280.

Hunter, T. 1985. At last the insulin receptor. Nature 313:740-741.

Coussens, P. M., Cooper, J. A., Hunter, T., and Shalloway, D. 1985. Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c‑src relative to pp60v‑src. Mol. Cell. Biol. 5:2753-2763.

Gould, K. L., Woodgett, J. R., Cooper, J. A., Buss, J. E., Shalloway, D., and Hunter, T. 1985. Protein kinase C phosphorylates pp60src at a novel site. Cell 42:849-857.

Cooper, J. A., and Hunter, T. 1985. Major substrate for growth factor activated protein-tyrosine kinases is a low-abundance protein. Mol. Cell. Biol. 5:3304-3309.

Hunter, T., and Cooper, J. A. 1986. Viral oncogenes and tyrosine phosphorylation. The Enzymes, Vol. XVII "Enzyme Control by Protein Phosphorylation" (P. D. Boyer and E. G. Krebs, eds), pp. 191-246.

Gould, K. L., Cooper, J. A., Bretscher, A., and Hunter, T. 1986. The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. J. Cell Biol. 102:660-669.

Cooper, J. A., Gould, K. L., Cartwright, C. A., and Hunter, T. 1986. Tyr527 is phosphorylated in pp60c‑src: implications for regulation. Science 231:1431-1434.

Cartwright, C. A., Kaplan, P. L., Cooper, J. A., Hunter, T., and Eckhart, W. 1986. Altered sites of tyrosine phosphorylation in pp60c‑srcassociated with polyomavirus middle tumor antigen. Mol. Cell. Biol. 6:1562-1570.

Patschinsky, T., Hunter, T., and Sefton, B. M. 1986. Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v‑src of Prague Rous sarcoma virus. J. Virol. 59:73-81.

Gould, K. L., Woodgett, J. R., Isacke, C. M., and Hunter, T. 1986. The protein-tyrosine kinase substrate, p36, is also a substrate for protein kinase C in vitro and in vivo. Mol. Cell. Biol. 6:2738-2744.

Isacke, C. M., Trowbridge, I. S., and Hunter, T. 1986. Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies. Mol. Cell. Biol. 6:2745-2751.

Saris, C. J. M., Tack B. F., Kristensen, T., Glenney, J. R., Jr., and Hunter, T. 1986. The cDNA sequence for the protein-tyrosine kinase substrate, p36 (calpactin I heavy chain), reveals a multidomain protein with internal repeats. Cell 46:201-212.

Kristensen, T., Saris, C. J. M., Hunter, T., Hicks, L. J., Noonan, D. J., Glenney, J. R., Jr., and Tack, B. F. 1986. Primary sequence of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor, lipocortin. Biochemistry 25:4497-4503.

Glenney, J. R., Jr., Boudreau, M., Galyean, R., Hunter, T., and Tack, B. 1986. Association of the S-100-related calpactin I light chain with the NH2-terminal domain of the 36-kDa heavy chain. J. Biol. Chem. 261:10485-10488.

Sefton, B. M. and Hunter, T. 1986. From c‑src to v‑src, or the case of the missing C terminus. Cancer Surveys Vol. 5, Biochemical Mechanisms of Oncogene Activity: Proteins encoded by oncogenes (H. E. Varmus, and J. M. Bishop, eds), pp. 159-172.

Hunter, T. 1986. Phosphorylation in signal transmission and transformation. In "Oncogenes and Growth Control" (P. Kahn and T.Graf, eds), pp. 138-146, Springer-Verlag, Heidelberg.

Tripp, M. L., Pinon, R., Meisenhelder, J., and Hunter, T. 1986. Identification of phosphoproteins correlated with proliferation and cell cycle arrest in Saccharomyces cerevisiae: positive and negative regulation by cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 83:5973-5977.

Isacke, C. M., Meisenhelder, J., Brown, K. D., Gould, K. L., Gould, S. J., and Hunter, T. 1986. Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide. EMBO J. 5:2889-2898.

Woodgett, J. R., Gould, K. L., and Hunter, T. 1986. Substrate specificity of protein kinase C: use of synthetic peptides mimicking physiological phosphorylation sites as probes for substrate recognition requirements. Eur. J. Biochem. 161:177-184.

Hunter, T. 1986. Cell growth control mechanisms. Nature 322:14-16.

Woodgett, J. R., and Hunter, T. 1987. Isolation and characterization of two distinct forms of protein kinase C. J. Biol. Chem. 262:4836-4843.

Woodgett, J. R., and Hunter, T. 1987. Immunological evidence for two physiological forms of protein kinase C. Mol. Cell. Biol. 7:85-96.

Cartwright, C. A., Simantov, R., Kaplan, P. L., Hunter, T., and Eckhart, W. 1987. Alterations in pp60c‑src accompany differentiation of neurons from rat embryo striatum. Mol. Cell. Biol. 7:1830-1840.

Saris, C. J. M., Kristensen, T., D'Eustachio, P., Hicks, L. J., Noonan, D. J., Hunter, T., and Tack, B. F. 1987. cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I). J. Biol. Chem. 262:10663-10671.

Woodgett, J. R., Hunter, T., and Gould K. L. 1987. Protein kinase C and its role in cell growth. In Cell Membranes: Methods and Reviews (E. L. Elson, W. A. Frazier and L. Glaser, eds), Vol. 3, pp. 215-340, Plenum Publishing Corporation, New York.

Woodgett, J. R., and Hunter, T. 1987. Regulation of protein kinase C by activators, Ca2+, and phosphoryl-ation. In Progress in Clinical and Biological Research, Vol. 249, Mechanisms of Signal Transduction by Hormones and Growth Factors (M. C. Cabot and W. L. McKeehan, eds), pp. 237-247, Alan R. Liss, New York.

Hunter, T. 1987. Oncogenes and "Psoriagenes". In Psoriasis, Proceedings of the Fourth International Symposium (E. M. Farber, L. Nall, V. Morhenn and P. H. Jacobs, eds), pp. 58-68, Elsevier, New York.

Hunter, T. 1987. A tail of two src's: mutatis mutandis. Cell 49:1-4.

Hunter, T. 1987. The role of phosphorylation in growth control and malignant transformation. In Signal Transduction and Protein Phosphorylation (L. Heilmeyer, ed, NATO ASI Series A: Life Sciences Vol. 135, pp. 329-344, Plenum Press, New York.

Bilezikjian, L. M., Woodgett, J. R., Hunter, T., and W. W. Vale. 1987. Phorbol ester induced down-regulation of protein kinase C abolishes vasopressin-mediated responses in rat anterior pituitary cells. Mol. Endocrinol. 1:555-560.

Hunter, T. 1987. A thousand and one protein kinases. Cell 50:823-829.

Hunter, T., Cartwright, C. A., Woodgett, J. R., and Gould, K. L. 1991. Phosphorylation of pp60c‑src. In P & S Biomedical Sciences Symposium on "Molecular Mechanisms in Cellular Growth and Differentiation" (A. R. Bellvé and H. J. Vogel, eds) pp. 25-43, Academic Press, New York.

Cartwright, C. A., Simantov, R., Cowan, W. M., Hunter, T., and Eckhart, W. 1988. pp60c‑src expression in the developing rat brain. Proc. Natl. Acad. Sci. USA 85:3348-3352.

Weinmaster, G. A., Middlemas, D. S., and Hunter, T. 1988. A major site of tyrosine phosphorylation within the SH2 domain of Fujinami sarcoma virus P130gag‑fps is not required for protein-tyrosine kinase activity or transforming potential. J. Virol. 62:2016-2025.

Angel, P., Allegretto, E., Okino, S., Hattori, K., Boyle, W. J., Hunter, T., and Karin, M. 1988. Oncogene jun encodes a sequence-specific trans-activator similar to AP‑1. Nature 332:166-171.

Hanks, S. K., Quinn, A. M., and Hunter, T. 1988. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42-52.

Hunter, T. 1988. The Ca2+/phospholipid-binding proteins of the cortical skeleton. In Advances in Experimental Medicine and Biology, Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction and Clinical Implications (J. E. Kudlow, D. H. MacLennan, A. Bernstein and A. I. Gotlieb, eds) Vol. 234, pp. 169-193, Plenum Press, New York.

Defize, L. H. K., Arndt-Jovin, D. J., Jovin, T. M., Boonstra, J., Meisenhelder, J., Hunter, T., de Hey, H. T., and de Laat, S. W. 1988. A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor receptor number, protein-tyrosine kinase activity and receptor turnover. J. Cell Biol. 107:939-949.

Weinmaster, G. A., and Hunter, T. 1988. Investigation of the role of P130gag‑fps in transformation: generation and use of a temperature-sensitive mutant P130gag‑fps. J. Virol. 62:3849-3854.

Gould, K. L., and Hunter, T. 1988. Platelet-derived growth factor induces multisite phosphorylation of pp60c‑src and increases its protein-tyrosine kinase activity. Mol. Cell. Biol. 8:3345-3356.

Chiu, R., Boyle, W. J., Meek, J., Smeal, T., Hunter, T., and Karin, M. 1988. The c‑fos protein interacts with c‑jun/AP‑1 to stimulate transcription of AP‑1 responsive genes. Cell 54:541-552.

Hunter, T., Angel, P., Boyle, W. J., Chiu, R., Freed, E., Gould, K. L., Isacke, C. M., Karin, M., Lindberg, R. A., and van der Geer, P. 1988. Targets for signal-transducing protein kinases. Cold Spring Harbor Symp. Quant Biol. 53:131-142.

Lindberg, R. A., Thompson, D. P., and Hunter. T. 1988. Identification of cDNA clones that code for protein-tyrosine kinases by screening expression libraries with antibodies against phosphotyrosine. Oncogene 3:629-633.

Hunter, T. 1989. The functions of oncogene products. Prog. Clin. Biol. Res. Vol. 288, Immunity to Cancer II (M. S. Mitchell, ed) pp. 25-34, Alan R. Liss, New York.

Isacke, C. M., Lindberg, R. A., and Hunter, T. 1989. The synthesis of p36 and p35 is increased when U‑937 cells differentiate in culture but expression is not inducible by glucocorticoids. Mol. Cell. Biol. 9:232-240.

Nunn, M. F., and Hunter, T. 1989. The ets sequence is required for induction of erythroblastosis in chickens by avian retrovirus E26. J. Virol. 63:398-402.

Gould, K. L., Bilezikjian, L., and Hunter, T. 1989. AtT20 cells express modified forms of pp60c‑src. Mol. Endocrinol. 3:79-88.

Hunter, T. 1989. Oncogene products in the cytoplasm: the protein kinases. In Oncogenes and the Molecular Origins of Cancer (R. A. Weinberg, ed) pp. 147-173, Cold Spring Harbor Laboratory Press.

Hunter, T., Gould, K. L., Lindberg, R. A., Meisenhelder, J., Middlemas, D. S., and Thompson, D. P. 1990. Protein-tyrosine kinases and their substrates: old friends and new faces. In Smith Kline & French Laboratories Research Symposium "Protein Design and the Development of New Therapeutics and Vaccines" (J. B. Hook and G. Poste, eds) pp. 119-139, Plenum Publishing Corp, New York.

Meisenhelder, J., Suh, P.-G., Rhee, S. G., and Hunter, T. 1989. Phospholipase C-g is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell 57:1109-1122.

Pines, J., and Hunter, T. 1989. Isolation of a human cyclin B cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell 58:833-846.

Freed, E., Gailit, J., van der Geer, P., Ruoslahti, E., and Hunter, T. 1989. A novel integrin b subunit is associated with the vitronectin receptor a subunit (av) in a human osteosarcoma cell line and is a substrate for protein kinase C. EMBO J. 8:2955-2965.

Defize, L. H. K., Boonstra, J., Meisenhelder, J., Kruijer, W., Tertoolen, L. G. J., Tilly, B. C., Hunter, T., van Bergen en Henegouwen, P. M. P., Moolenaar, W. H., and de Laat, S. W. 1989. Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors. J. Cell Biol. 109:2495-2507.

Gould, K. L., Bretscher, A., Esch, F. S., and Hunter, T. 1989. cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO J. 8:4133-4142.

Bull, P., Hunter, T., and Verma, I. M. 1989. Transcriptional induction of the murine c‑rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts. Mol. Cell. Biol. 9:5239-5243.

Hunter, T. 1989. Protein-tyrosine phosphatases: the other side of the coin. Cell 58:1013-1016.

Hunter, T. Protein modification: phosphorylation of tyrosine residues. 1989. Curr. Opin. Cell Biol. 1:1168-1187.

Amiguet, P., D'Eustachio, P., Kristensen, T., Wetsel, R. A., Saris, C. J. M., Hunter, T., Chaplin, D. D., and Tack, B. F. 1990. Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene. Biochemistry 29:1226-1232.

Isacke, C. M., van der Geer, P., Hunter, T., and Trowbridge, I. S. 1990. p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Mol. Cell. Biol. 10:2606-2618.

Hunter, T., Lindberg, R. A., and Middlemas, D. S. 1990. Novel receptor protein-tyrosine kinases. Advances in Second Messenger and Phosphoprotein Research Vol. 24:260-265.

van der Geer, P., and Hunter, T. 1990. Identification of tyrosine 706 in the kinase insert as the major CSF-1-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line. Mol. Cell. Biol. 10:2991-3002.

Pines, J., and Hunter, T. 1990. p34cdc2: the S and M kinase. New Biol. 2:389-401.

Bull, P., Morley, K. L., Hoekstra, M. F., Hunter, T., and Verma, I. M. 1990. The mouse c‑rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. Mol. Cell. Biol. 10:5473-5485.

Pines, J., and Hunter, T. 1990. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature 346:760-763.

Lindberg, R. A., and Hunter, T. 1990. cDNA cloning and characterization of eck, an epithelial cell receptor-like protein-tyrosine kinase in the eph/elk family of protein kinases. Mol. Cell. Biol. 10:6316-6324.

Yamashita, K., Yasuda, H., Pines, J., Yasumoto, K., Nishitani, H., Ohtsubo, M., Hunter, T., Sugimura, T., and Nishimoto, T. 1990. Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells. EMBO J. 9:4331-4338.

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