Salk Institute

Hunter Lab

Publications

Publications 1991 - 2000

Cochet, C., Filhol, O., Payrastre, B., Hunter, T., and Gill, G. N. 1991. Interaction between the epidermal growth factor receptor and phosphoinositide kinases. J. Biol. Chem. 266:637-644.

Middlemas, D. S., Lindberg, R. A., and Hunter, T. 1991. trkB, a neural receptor protein-tyrosine kinase: evidence for full-length and two truncated receptors. Mol. Cell. Biol. 11:143-153.

Boyle, W. J., Smeal, T., Defize, L. H. K., Angel, P., Woodgett, J. R., Karin, M., and Hunter, T. 1991. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64:573-584.

Meisenhelder, J., and Hunter, T. 1991. Methods for studying the phosphorylation of phospholipase C in vivo and in vitro. Meth. Enzymol. 197:288-305.

Hunter, T. 1991. Protein kinase classification. Meth. Enzymol. 200:3-37.

Boyle, W. J., van der Geer, P., and Hunter, T. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin layer cellulose plates. Meth. Enzymol. 201:110-149.

Inoue, J.-I., Kerr, L. D., Ransone, L. J., Bengal, E., Hunter, T., and Verma, I. M. 1991. c-rel activates but v-rel suppresses transcription from kB sites. Proc. Natl. Acad. Sci. USA 88:3715-3719.

Nishitani, H., Ohtsubo, M., Yamashita, K., Iida, H., Pines, J., Yasuda, H., Shibata, Y., Hunter, T., and Nishimoto, T. 1991. Loss of RCC1, a nuclear DNA binding protein, uncouples the completion of DNA replication from activation of the cdc2 protein kinase and mitosis. EMBO J. 10:1555-1564.

Hunter, T., and Pines, J. 1991. The role of cyclins in human cell division. GMCRF Accomplishments in Cancer Research 1990, pp. 186-194.

Hunter, T. 1991. Cooperation between oncogenes. Cell 64:249-270.

Hunter, T. 1991. Protein-serine kinase receptors? Curr. Biol. 1:15-16.

Pines, J., and Hunter, T. 1991. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle dependent nuclear transport. J. Cell Biol. 115:1-17.

van der Geer, P., and Hunter, T. 1991. Tyrosine 706 and 807 phosphorylation site mutants in the murine CSF‑1 receptor are unaffected in their ability to bind or phosphorylate PI-3 kinase but show differential defects in their ability to induce early response gene transcription. Mol. Cell. Biol. 11:4698-4709.

Jähner, D., and Hunter, T. 1991. The ras-related gene rhoB is an immediate early gene inducible by v‑Fps, epidermal growth factor and platelet-derived growth factor in rat fibroblasts. Mol. Cell. Biol. 11:3682-3690.

Jähner, D., and Hunter, T. 1991. The stimulation of quiescent rat fibroblasts by the v‑src and v‑fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes. Oncogene 6:1259-1268.

Mudryj, M., Devoto, S. H., Hiebert, S. W., Hunter, T., Pines, J., and Nevins, J. R. 1991. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 65:1243-1253.

Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Reid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., Nikolics, K., and Parada, L. F. 1991. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 65:895-903.

Pines, J., and Hunter, T. 1991. Human cell division: the involvement of cyclins A and B1, and multiple cdc2s. Cold Spring Harbor Symp. Quant. Biol. 56:449-461.

Nevins, J. R., Chellapan, S. P., Mudryj, M., Hiebert, S., Devoto, S., Horowitz, J., Hunter, T., and Pines, J. 1991. E2F transcription factor is a target for the RB protein and the cyclin A protein. Cold Spring Harbor Symp. Quant. Biol. 56:157-162.

Hunter, T., and Pines, J. 1991. Cyclins and cancer. Cell 66:171-174.

Pines, J., and Hunter, T. 1991. Cyclin-dependent kinases: a new cell cycle motif? Trends Cell Biol. 1:117-121.

O'Connor, P. M., Ferris, D. K., White, G. A., Pines, J., Hunter, T., Longo, D. L., and Kohn, K. W. 1992. Relationship between cdc2 kinase, DNA crosslinking and cell cycle perturbations induced by nitrogen mustard. Cell Growth Diff. 3:43-52.

Devoto, S. H., Mudryj, M., Pines, J., Hunter, T., and Nevins, J. R. 1992. A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell 68:167-176.

Lock, L. F., Pines, J., Hunter, T., Gilbert, D. J., Gopalan, G., Jenkins, N. A., Copeland, N. G., and Donovan, P. J. 1992. A single cyclin A gene and multiple cyclin B1-related sequences are dispersed in the mouse genome. Genomics 13:415-424.

Bailly, E., Pines, J., Hunter, T., and Bornens, M. 1992. Cytoplasmic accumulation of cyclin B1 in human cells: association with a Triton-insoluble compartment and with the centrosome. J. Cell Sci. 101:529-545.

Hamaguchi, J. R., Tobey, R. A., Pines, J., Crissman, H. A., Breneman, J. R., Hunter, T., and Bradbury, M. 1992. Cell cycle analysis of histone H1 kinases in the mammalian CDC2 mutant FT210. J. Cell Biol. 117:1041-1053.

Freed, E., and Hunter, T. 1992. A 41 kilodalton protein is a potential substrate for the p210bcr-abl protein-tyrosine kinase in chronic myelogenous leukemia cells. Mol. Cell. Biol. 12:1312-1323.

Reedijk, M., Liu, X., van der Geer, P., Letwin, K., Waterfield, M. D., Hunter, T., and Pawson, T. 1992. Tyr721 regulates specific binding of the CSF‑1 receptor kinase insert to PI 3' kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J. 11:1365-1372.

van der Geer, P., Luo, K., Sefton, B. M., and Hunter, T. 1993. Phosphopeptide mapping and phosphoamino acid analysis on cellulose thin layer plates. In Protein Phosphorylation: A Practical Approach, Vol. 2, pp. 31-59 (D. G. Hardie, ed), Oxford University Press. Second edition, 1999, pp. 97-126.

Lu, X. P., Koch, K. S., Lew, D. J., Dulic, V., Pines, J., Reed, S. I., Hunter, T., and Leffert, H. L. 1992. Induction of cyclin mRNA and cyclin-associated histone H1-kinase during liver regeneration. J. Biol. Chem. 267:2841-2844.

Hunter, T. 1992. Regulation of the eukaryotic cell cycle; introduction. In CIBA Symposium 170, Regulation of the eukaryotic cell cycle, pp. 1-6, John Wiley and Sons, Chichester, England.

Lindberg, R. A, Quinn, A. M., and Hunter, T. 1992. Dual-specificity protein kinases: will any hydroxyl do? Trends Biochem. Sci. 17:114-118.

DeMaggio, A. J., Lindberg, R. A., Hunter, T., and Hoekstra, M. F. 1992. The budding yeast HRR25 gene product is a casein kinase I isoform. Proc. Natl. Acad. Sci. USA 89:7008-7012.

Kakizuka, A., Sebastian, B., Borgmeyer, U., Hermans-Borgmeyer, I., Bolado, J., Hunter, T., Hoekstra, M., and Evans, R. M. 1992. A mouse cdc25 homologue is differentially and developmentally expressed. Genes Dev. 6:578-590.

Pines, J., and Hunter, T. 1992. Cyclins A and B1 in the human cell cycle. In CIBA Symposium 170, Regulation of the eukaryotic cell cycle, pp. 187-196, John Wiley and Sons, Chichester, England.

Krieg, J., and Hunter, T. 1992. Identification of the two major, EGF-induced tyrosine phosphorylation sites in the microvillar core protein ezrin. J. Biol. Chem. 267:19258-19265.

Hunter, T., Lindberg, R. A., Middlemas, D. S., Tracy, S., and van der Geer, P. 1992. Receptor protein-tyrosine kinases and phosphatases. Cold Spring Harbor Symp. Quant. Biol. 57:25-41.

Lin, A., Frost, J., Deng, T., Smeal, T., Al-Alawi, N., Kikkawa, U., Hunter, T., Brenner, D., and Karin, M. 1992. Casein kinase II is a negative regulator of c-Jun DNA binding and AP‑1 activity. Cell 70:777-789.

Kikkawa, U., Mann, S. K. O., Firtel, R. A., and Hunter, T. 1992. Molecular cloning of casein kinase II a subunit from Dictyostelium discoideum, and its expression in the life cycle. Mol. Cell. Biol. 12:5711-5723.

Hunter, T., and Karin, M. 1992. The regulation of transcription by phosphorylation. Cell 70:375-387.

Meisenhelder, J., and Hunter, T. 1992. The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-g1 monoclonal antibodies and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. Mol. Cell. Biol. 12:5843-5856.

Frisen, J., Verge, V. M. K., Cullheim, S., Persson, H., Fried, K., Middlemas, D. S., Hunter, T., Hökfelt, T., and Risling, M. 1992. Upregulation of trkB mRNA and trkB gene protein-like immunoreactivity in the injured rat and cat spinal cord. Proc. Natl. Acad. Sci. USA 89:11282-11286.

Lindberg, R. A., Fischer, W. H., and Hunter, T. 1993. Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine. Oncogene 8:351-359.

Merlio, J.-P., Ernfors, P., Kokaia, Z., Middlemas, D. S., Bengzon, J., Kokaia, M., Smith, M.‑L., Siesjö, B. K., Hunter, T., Lindvall, O., and Persson, H. 1993. Increased production of the TrkB protein-tyrosine kinase receptor after brain insults. Neuron 10:151-164.

Sebastian, B., Kakizuka, A., and Hunter, T. 1993. Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. Proc. Natl. Acad. Sci. USA 90:3521-3524.

O'Connor, P. M., Ferris, D. K., Pagano, M., Draetta, G., Pines, J., Hunter, T., Longo, D. L., and Kohn, K. W. 1993. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2 kinase complexes differently. J. Biol. Chem. 268:8298-8308.

Trautwein, C., Caelles, C., van der Geer, P., Hunter, T., Karin, M., and Chojkier, M. 1993. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature 364:544-547.

Hunter, T., and Simon, S. 1993. pp60c‑src. In Guidebook to Cytoskeletal and Motor Proteins (T. Kreis and R. Vale, eds), pp. 236-238, Sambrook and Tooze, Oxford University Press.

Hunter, T. 1993. Receptor protein-tyrosine kinases and phosphatases and their substrates. In Klinische Pharmakologie Vol. 9, Frontiers in Biomedical Research (D. Hartmann, Y. Furiuchi and J. Drews, eds), pp. 122-136, W. Zuckschwerdt Verlag, München.

Hunter, T. 1993. Oncogenes and the cell cycle. Curr. Opin. Genet. Develop. 3:1-4.

van der Geer, P., and Hunter, T. 1993. Mutation of Tyr697, a GRB-2 binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat‑2 fibroblasts. EMBO J. 12:5161-5172.

Hunter, T. 1993. Braking the cycle. Cell 75:839-841.

Hunter, T. 1993. Cytokine connections. Nature 366:114-116.

Middlemas, D. S., Meisenhelder, J., and Hunter, T. 1994. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-g1 is a substrate of the TrkB receptor. J. Biol. Chem. 269:5458-5466.

Pawson, T., and Hunter, T. 1994. Signal transduction in normal and cancer cells. Curr. Opin. Genet. Develop. 4:1-4.

Kornbluth, S., Sebastian, B., Hunter, T., and Newport, J. 1994. Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. Mol. Biol. Cell 5:273-282.

Rigaudy, P., Simon, S., Hunter, T., Sollazzo, M., Billetta, R., Zanetti, M., and Eckhart, W. 1994. Antibodies specific for the neuronal form of the Src protein elicited by an antigenized antibody. DNA Cell Biol. 13:585-591.

Bartley, T. D., Hunt, R. W., Welcher, A. A., Boyle, W. J., Parker, V. P., Lindberg, R. A., Lu, H. S., Colombero, A. M., Elliot, R. L., Guthrie, B. A., Holst, P. L., Skrine, J. D., Toso, R. J., Zhang, M., Fernandez, E., Trail, G., Varnum, B., Yarden, Y., Hunter, T., and Fox, G. M. 1994. B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature 368:558-560.

Trautwein, C., van der Geer, P., Karin, M., Hunter, T., and Chojkier, M. 1994. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J. Clin. Invest. 93:2554-2561.

den Hertog, J., Tracy, S., and Hunter, T. 1994. Phosphorylation of receptor protein-tyrosine phosphatase a on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo. EMBO J. 13:3020-3032.

van der Geer, P., and Hunter, T. 1994. Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates. Electrophoresis 15:544-554.

Toyoshima, H., and Hunter, T. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78:67-74.

Zhang, S.-H., Lawton, M. A., Hunter, T., and Lamb, C. J. 1994. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization and expression. J. Biol. Chem. 269:17586-17592.

Zhang, S.-H., Broome, M. A., Lawton, M. A., Hunter, T., and Lamb, C. J. 1994. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. II. Functional and biochemical analysis of the encoded protein. J. Biol. Chem. 269:7593-17599.

Howard, P. K., Gamper, M., Hunter, T., and Firtel, R. A. 1994. Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development. Mol. Cell. Biol.               14:5154-5164.

Pines, J., and Hunter, T. 1994. The different localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO J. 13:3772-3781.

Hoekstra, M. F., Dhillon, N., Carmel, G., DeMaggio, A. J., Lindberg, R. A., Hunter, T., and Kuret, J. 1994. Budding and fission yeast casein kinase I isoforms have dual-specificity protein kinase activity. Mol. Biol. Cell 5:877-886.

van der Geer, P., Hunter, T., and Lindberg, R. A. 1994. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10:251-337.

Hunter, T., and Lindberg, R. A. 1994. Receptor protein-tyrosine kinases. In Protein Kinases: Frontiers in Molecular Biology (J. R. Woodgett, ed), pp. 177-211, Oxford University Press.

van der Geer, P., Luo, K., Sefton, B. M., and Hunter, T. 1994. Phosphopeptide mapping and phosphoamino acid analysis on cellulose thin layer plates. In Cell Biology: A Laboratory Handbook (J. E. Celis, ed), pp.‑422-448, Aacdemic Press, London.

Hunter, T. 1994. 1001 protein kinases redux - towards 2000. Seminars Cell Biol. 5:367-376.

Hunter, T., and Pines, J. 1994. Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79:573-582.

Schlaepfer, D. D., Hanks, S. K., Hunter, T., and van der Geer, P. 1994. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372:786-791.

Hunter, T. 1995. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80:225-236.

Hanks, S. K., and Hunter, T. 1995. The eukaryotic protein kinase superfamily. In The Protein Kinase FactsBook (G. Hardie and S. Hanks, eds), pp. 7-47, Academic Press, London.

Hunter, T., and Lindberg, R. A. 1995. Eck - Epithelial cell kinase. In The Protein Kinase FactsBook.Protein-Tyrosine Kinases (G. Hardie and S. Hanks, eds), pp. 139-141, Academic Press, London.

Pines, J., and Hunter, T. 1995. Cyclin-dependent kinases: an embarrassment of riches? In The Cell Cycle: Frontiers in Molecular Biology (D. M. Glover and C. Hutchison, eds), pp. 144-176, Oxford University Press.

Hanks, S. K., and Hunter, T. 1995. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9:576-596.

Watanabe, N., Broome, M., and Hunter, T. 1995. Regulation of the WEE1Hu human CDK tyrosine 15-kinase during the cell cycle. EMBO J. 14:1878-1891.

Karin, M., and Hunter, T. 1995. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr. Biol. 5:747-757.

Lu, K. P., and Hunter, T. 1995. Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell 81:413-424.

Poon, R. Y. C., Toyoshima, H., and Hunter, T. 1995. Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or UV irradiation. Mol. Biol. Cell 6:1197-1213.

Haley, A., Hunter, T., Kiberstis, P., and Zimmern, D. 1995. Multiple serine phosphorylation sites on the 30 kDa TMV cell-to-cell movement protein synthesized in tobacco protoplasts. Plant J. 8:715-724.

Sekiguchi, T., Nakashima, T., Hayashida, T., Kuraoka, A., Hashimoto, S., Tsuchida, N., Shibata, Y., Hunter, T., and Nishimoto, T. 1995. Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFII250 subunit of the TFIID basal transcription factor. Exp. Cell Res. 218:490-498.

Tracy, S., van der Geer, P., and Hunter, T. 1995. The receptor-like protein-tyrosine phosphatase RPTPa is phosphorylated by protein kinase C at two serines close to the inner face of the transmembrane domain. J. Biol. Chem. 270:10587-10594.

Hunter T. 1995. Tyrosine phosphorylation: past, present and future. In Accomplishments in Cancer Research 1994. General Motors Cancer Research Foundation (J. G. Fortner and J. E. Rhoads, eds), pp. 43-63, J. B. Lippincott, Philadelphia, Pennsylvania.

Neet, K., and Hunter, T. 1995. The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src. Mol. Cell. Biol. 15:4908-4920.

Poon, R. Y. C., and Hunter, T. 1995. Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Science 270:90-93.

Lu, K. P., and Hunter, T. 1995. The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. In Progress in Cell Cycle Research (L. Meijer, S. Guidet and H. Y. L. Tung, eds), 1:187-205, Plenum Press, New York.

Gamper, M., Howard, P. K., Hunter, T. and. Firtel, R. A. 1995. Protein tyrosine phosphatases in Dictyostelium discoideum. Adv. Protein Phosphatases 9:25-49.

Poon, R. Y. C., and Hunter, T. 1995. Innocent bystanders or chosen collaborators? Curr. Biol. 5:1243-1247.

Hunter, T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. 1995. Cell 83:1-4.

Taylor, S. S., Radzio-Andzelm, E., and Hunter, T. 1995. How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase. FASEB J. 9:1255-1266.

Winston, L. A., and Hunter, T. 1995. JAK2, Ras and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. J. Biol. Chem. 270:30837-30840.

Fang, F., Orend, G., Watanabe, N., Hunter, T., and Ruoslahti, E. 1996. Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science 271:499-502.

Mal, A., Howe, P. H., Toyoshima, H., Poon, R. Y. C., Hunter, T., and Harter, M. L. 1996. Inactivation of p27Kip1 by the viral E1A oncoprotein in TGF-treated cells. Nature 380:262-265.

Fey, M. F., Moffat, G. J., Vik, D. P., Meisenhelder, J., Saris, C. J. M., Hunter, T., and Tack, B. F. 1996. Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5’ noncoding exons. Biochim. Biophys. Acta 1306:160-170.

den Hertog, J., and Hunter, T. 1996. Tight association of GRB2 with receptor protein-tyrosine phosphatase is mediated by the SH2 and C-terminal SH3 domains. EMBO J. 15:3016-3027.

Ezhevsky, S. A., Toyoshima, H., Hunter, T., and Scott, D. W. 1996. Role of cyclin A and p27 in anti-IgM-induced G1 growth arrest of murine B-cell lymphomas. Mol. Biol. Cell. 7:553-564.

Lu, K. P., Hanes, S. D., and Hunter, T. 1996. A human peptidyl-proline isomerase essential for regulation of mitosis. Nature 380:544-547.

Neet, K., and Hunter, T. 1996. Vertebrate non-receptor protein-tyrosine kinase families. Genes Cells 1:147-169.

Gamper, M., Howard, P. K., Hunter, T. and Firtel, R. A. 1996. Multiple roles of the novel protein-tyrosine phosphatase 3 during Dictyostelium growth and development. Mol. Cell. Biol. 16:2431-2444.

Poon, R. Y. C., Jiang, W., Toyoshima, H., and Hunter, T. 1996. Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J. Biol. Chem. 271:13283-13291.

Broome, M. A., and Hunter, T. 1996. Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. J. Biol. Chem. 271:16798-16806.

Hunter T. 1996. Tyrosine phosphorylation: past, present and future. Biochem. Soc. Transact. 24:307-327.

Winston, L. A., and Hunter, T. 1996. Putting JAKs on the kinase MAP. Curr. Biol. 6:668-671.

Hunter, T. 1996. Solid-state protein networks? Trends Cell Biol. 6:254-255.

Sekiguchi, T., Noguchi, E., Hayashida, T., Nakashima, T., Toyoshima, H., Nishimoto, T., and Hunter, T. 1996. D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature. Genes Cells 1:687-705.

Schlaepfer, D. D., and Hunter, T. 1996. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src family protein-tyrosine kinases. Mol. Cell. Biol. 16:5623-5633.

Bilwes, A. M., den Hertog, J., Hunter, T., and Noel, J. P. 1996. Structural basis for inhibition of receptor protein-tyrosine phosphatase- activity by dimerization. Nature 382:555-559.

Janknecht, R., and Hunter, T. 1996. Transcriptional control: versatile molecular glue. Curr. Biol. 6:951-954.

Janknecht, R., and Hunter, T. 1996. A growing coactivator network. Nature 381:22-23.

Songyang, Z., Lu, K. P., Kwon, Y. T., Tsai, L.-H., Filhol, O., Cochet, C., Brickey, D. A., Soderling, T. R., Bartleson, C., Graves, D. J., DeMaggio, A. J., Hoekstra, M. F., Blenis, J., Hunter, T., and Cantley, L. C. 1996. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol. Cell. Biol. 16:6486-6493.

Poon, R. Y. C, Toyoshima, H., and Hunter, T. 1996. On the masking of signals on immunoblots by cellular proteins. J. Immunol. Meth. 199:155-158.

Horwitz, A. F., and Hunter, T. 1996. Cell adhesion: integrating circuitry. Trends Cell Biol. 6:480-481.

Schlaepfer, D. D., and Hunter, T. 1996. Signal transduction from the extracellular matrix - a role for the focal adhesion protein-tyrosine kinase FAK. Cell Struct. Funct. 21:445-450.

Ofir, R., Weinstein, Y., Bazarsky, E., Blagerman, S., Wolfson, M., Hunter, T., and Rager-Zisman, B. 1996. Tyrosine phosphorylation of measles virus P-phosphoprotein in persistently infected neuroblastoma cells. Virus Genes 13:203-210.

Broome, M. A., and Hunter, T. 1997. The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide binding. Oncogene 14:17-34.

Fukunaga, R., and Hunter, T. 1997. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method to identify protein kinase substrates. EMBO J. 16:1921-1933.

Janknecht, R., and Hunter, T. 1997. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J. 16:1620-1627.

Janknecht, R., and Hunter, T. 1997. Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. J. Biol. Chem. 272:4219-4224.

Poon, R. Y. C., Lew, J., and Hunter, T. 1997. Identification of functional domains in the neuronal Cdk5 activator protein. J. Biol. Chem. 272:5703-5708.

Hunter, T., and Plowman, G. D. 1997. The protein kinases of yeast: six score and more. Trends Biochem. Sci. 22:18-22.

Hunter, T. 1997. Oncoprotein networks. Cell 88:333-346.

Hunter, T., and Poon, R. Y. C. 1997. Cdc37; a protein kinase chaperone? Trends Cell Biol. 7:157-161.

Schlaepfer, D. D., Broome, M. A., and Hunter, T. 1997. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol. Cell. Biol. 17:1702-1713.

Schlaepfer, D. D., and Hunter, T. 1997. Focal adhesion kinase overexpression enhances Ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c‑Src. J. Biol. Chem. 272:13189-13195.

Lu, K. P., and Hunter, T. 1997. Pin1. In Guidebook to Molecular Chaperones and Protein Folding Catalysts (M.-J. Gething, ed), pp. 443-446, Sambrook and Tooze, Oxford University Press.

Hunter, T. 1997. Oncogenes, growth suppressor genes and cancer. In Genes & Genomes II: Understanding and Manipulating Biological Systems (M. Singer and P. Berg, eds), pp. 203-269, University Science Books, Mill Valley, California.

Ranganathan, R, Lu, K. P., Hunter, T., and Noel, J. 1997. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell 89:875-886.

Stein, B., Yang, M. X., Young, D. B., Janknecht, R., Hunter, T., Murray, B. W., and Barbosa, M. S. 1997. p38‑2, a novel mitogen-activated protein kinase with distinct properties. J. Biol. Chem. 272:19509-19517.

Fischer, W. H., Hoeger, C. A., Meisenhelder, J., Hunter, T., and Craig, A. G. 1997. Determination of phosphorylation sites in peptides and proteins employing a volatile Edman reagent. J. Prot. Sci. 16:329-334.

Sakamoto, Y., Yoshida, M., Semba, K., and Hunter, T. 1997. Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain. Oncogene 15:2001-2012.

Shen, M., Haggblom, C., Vogt, M., Hunter, T., and Lu, K. P. 1997. Characteriztion and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis. Proc. Natl. Acad. Sci. USA 94:13618-13623.

Poon, R. Y. C., Chau, M. S., Yamashita, K., and Hunter, T. 1997. The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res. 57:5168-5178.

Li, S., Kim, M., Hu, Y.-L, Jalali, S., Schlaepfer, D. D., Hunter, T., Chien, S., and Shyy, J. Y.-J. 1997. Fluid shear stress activation of focal adhesion kinase: linking to mitogen-activated protein kinases. J. Biol. Chem. 272:30455-30462.

Gaarde, W. A., Hunter, T., Brady, H., Murray, B. W., and Goldman, M. E. 1997. Development of a non-radioactive, time-resolved fluorescence assay for the measurement of Jun N-terminal kinase activity. J. Biomol. Screening 2:213-223.

Jiang, W., and Hunter, T. 1997. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. Proc. Natl. Acad. Sci. USA 94:14320-14325.

Sekiguchi, T., and Hunter, T. 1998. Induction of growth arrest and cell death by overexpression of the p21 cyclin/Cdk inhibitor in hamster BHK21 cells. Oncogene 16:369-380.

Majeti, R., Bilwes, A. M., Noel, J. P., Hunter, T., and Weiss, A. 1998. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science 279:88-91.

Hunter, T. 1998. Prolyl isomerases and nuclear function. Cell 92:141-143.

Potter, L. R., and Hunter, T. 1998. Phosphorylation of the kinase homology domain is essential for activation of the A-type atrial natriuretic peptide receptor. Mol. Cell. Biol. 18:2164-2172.

Hunter, T. 1998. The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease. Phil. Trans. R. Soc. Lond. B Biol. Sci. 353:583-605.

Orend, G., Hunter, T., and Ruoslahti, E. 1998. Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells. Oncogene 16:2575-2583.

Schlaepfer, D. D., Jones, K. C., and Hunter, T. 1998. Multiple Grb2-mediated integrin-signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol. Cell. Biol. 18:2571-2585.

Jiang, W., and Hunter, T. 1998. Analysis of cell-cycle profiles in transfected cells using a membrane-targeted GFP. BioTechniques 24:348-353.

Schlaepfer, D. D., and Hunter, T. 1998. Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol. 8:151-157.

Hunter, T. 1998. Anti-phosphatases take the stage. Nature Genet. 18:303-305.

Poon, R. Y. C., and Hunter, T. 1998. Expression of a novel form of p21Cip1/Waf1 in UV-irradiated and transformed cells. Oncogene 16:1333 -1343.

Potter, L. R., and Hunter, T. 1998. Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor. J. Biol. Chem. 273:15533-15539.

Herdegen, T., Claret, F.-X., Kallunki, T., Martin-Villalba, A., Winter, C., Hunter, T., and Karin, M. 1998. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J. Neurosci. 18:5124-5135.

Hunter, T., and Simon, S. 1999. pp60c‑src. In Guidebook to Extracellular Matrix, Anchor, and Adhesion Proteins (T. Kreis and R. Vale, eds), pp. 62-67, Sambrook and Tooze, Oxford University Press.

Blume-Jensen, P., Janknecht, R., and Hunter. T. 1998. The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr. Biol. 8:779-782.

Janknecht, R., Wells, N. J., and Hunter, T. 1998. TGF--stimulated cooperation of Smad proteins with the coactivators CBP/p300. Genes Dev. 12:2114-2119.

Sieg, D. J., Ilic, D., Jones, K. C., Damsky, C. H., Hunter, T., and Schlaepfer, D. D. 1998. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration. EMBO J. 17:5933-5947.

Jiang, W., Jimenez, G., Wells, N. J., Hope, T. J., Wahl, G. M., Hunter, T., and Fukunaga, R. 1998. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol. Cell. 2:877-885.

Fukunaga, R., and Hunter, T. 1999. Identifying protein kinase substrates by expression screening with solid-phase phosphorylation. In Protein Phosphorylation: A Practical Approach, Vol. 2, pp. 291-313 (D. G. Hardie, ed), Oxford University Press.

Sekiguchi, T., Nishimoto, T., and Hunter, T. 1999. Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAFII250 mutation. Oncogene 18:1797-1806.

Pyronnet, S., Imataka, H., Gingras, A.-C., Fukunaga, R., Hunter, T., and Sonenberg, N. 1999. Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E. EMBO J. 18:270-279.

Potter, L. R., and Hunter, T. 1999. A constitutively “phosphorylated” guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitization. Mol. Biol. Cell 10:1811-1820.

Gamper, M., Kim, E., Howard, P. K., Ma, H., Hunter, T., and Firtel, R. A. 1999. Regulation of Dictyostelium protein-tyrosine phosphatase-3 (PTP3) through osmotic shock and stress stimulation and identification of pp130 as a PTP3 substrate pp130. J. Biol. Chem. 274:12129-12138.

Janknecht, R., and Hunter, T. 1999. Nuclear fusion of signaling pathways. Science 284:443-444.

Jiang, W., Wells, N. J., and Hunter, T. 1999. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc. Natl. Acad. Sci. USA 96:6193-6198.

Ruffner, H., Jiang, W., Craig, A. G., Hunter, T., and Verma, I. M. 1999. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Mol. Cell. Biol. 19:4843-4854.

Wells, N. J., Watanabe, N., Tokusumi, T., Jiang, W., Verdecia, M. A., and Hunter, T. 1999. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G2/M progression. J. Cell Sci. 112:3361-3371.

Biggs, W. H., III, Meisenhelder, J., Hunter, T., Cavenee, W. K., and Arden, K. C. 1999. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA 96:7421-7426.

Pearson, K. L., Hunter, T., and Janknecht, R. 1999. Activation of Smad1-mediated transcription by p300 and the CREB-binding protein. Biochim. Biophys. Acta 1489:354-364.

Jiang, G., and Hunter, T. 1999. Receptor signaling: when dimerization is not enough. Curr. Biol. 9:R568-571.

Zheng, C., Xiang, J., Hunter, T., and Lin, A. 1999. The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcriptional activity. J. Biol. Chem. 274:28966-29877.

Jiang, W., McDonald, D., Hope, T. J., and Hunter, T. 1999. Mammalian Cdc7/Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J. 18:5703-5713.

Jiang, G., den Hertog, J., Su, J., Noel, J., Sap, J., and Hunter, T. 1999. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-. Nature 401:606-610.

Joazeiro, C. A. P., Wing, S. S., Huang, H.-K., Leverson, J. D., Hunter, T., and Liu, Y.-C. 1999. The tyrosine kinase negative regulator, c-Cbl, as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286:309-312.

Palmer, R. H., Fessler, L. I., Edeen, P. T., Madigan, S. J., McKeown, M., and Hunter, T. 1999. DFak56 is a novel Drosophila melanogaster focal adhesion kinase. J. Biol. Chem. 274:35621-35629.

Plowman, G. D., Sudarsanam, S., Bingham, J., Whyte, D., and Hunter, T. 1999. The protein kinases of C. elegans: a model for signal transduction in multicellular organisms. Proc. Natl. Acad. Sci. USA 96:13603-13610.

Potter, L. R., and Hunter, T. 1999. Identification and characterization of phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B. Methods 19:506-520.

Buck, M., Poli, V., van der Geer, P., Chojkier, M., and Hunter, T. 1999. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP is required for hepatocyte proliferation induced by TGF. Mol. Cell 4:1087-1092.

Hunter, T. 2000. Signaling - 2000 and beyond. Cell 100:113-127.

Blume-Jensen, P., Jiang, G., Hyman, R., Lee, K.-F., O’Gorman, S., and Hunter, T. 2000. Kit/stem cell factor receptor-induced phosphatidylinositol 3’ kinase is essential for male fertility. Nature Genet. 24:157-162.

Xu, S., Huang, H.-K., Kaiser, P., Latterich, M., and Hunter, T. 2000. Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast. Curr. Biol. 10:329-332.

Pao, G. M., Janknecht, R., Ruffner, H., Hunter, T., and Verma, I. M. 2000. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc. Natl. Acad. Sci. USA 97:1020-1025.

Mal, A., Chattopadhyay, D., Ghosh, M. K., Poon. R. Y. C., Hunter, T., and Harter, M. L. 2000. p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells. J. Cell Biol. 149:281-292.

Verdecia, M. A., Huang, H.-K., Dutil, E., Kaiser, D. A., Hunter, T., and Noel, J. P. 2000. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nature Struct. Biol. 7:602-608.

Leverson, J. D., Joazeiro, C. A. P., Page, A. M., Huang, H.-K., Hieter, P. A., and Hunter, T. 2000. The APC11 RING-H2 finger mediates E2-dependent ubiquitination. Mol. Biol. Cell 11:2315-2325.

Huang, H.-K., Joazeiro, C. A. P., Bonfoco, E., Kamada, S., Leverson, J. D., and Hunter, T. 2000. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. J. Biol. Chem. 275:26661-26664.

Jiang, G., den Hertog, J., and Hunter, T. 2000. Receptor-like protein tyrosine phosphatase homodimerizes on the cell surface. Mol. Cell. Biol. 20:5917-5929.

Verdecia, M. A., Bowman, M. E., Lu, K. P., Hunter, T., and Noel, J. P. 2000. Structural basis for phosphoserine-proline recognition by group IV WW domains. Nature Struct. Biol. 7:639-643.

Friedrichsen, D. M., Joazeiro, C. A., Li, J., Hunter, T., and Chory, J. 2000. Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant. Physiol. 123:1247-1256.

Potter, L. R., and Hunter, T. 2000. Activation of protein kinase C stimulates the dephosphorylation of natriuretic peptide receptor-B at a single serine residue: a possible mechanism of heterologous desensitization. J. Biol. Chem. 275:31099-31106.

Qiu, L., Joazeiro, C., Fang, N., Wang, H. Y., Elly, C., Altman, Y., Fang, D., Hunter. T., and Liu, Y. C. 2000. Recognition and ubiquitination of Notch by Itch, a Hect-type E3 ubiquitin ligase. J. Biol. Chem. 275:35734-35737.

Hefner, Y., Börsch-Haubold, A. G., Murakami, M., Wilde, J. I., Pasquet, S., Schieltz, D., Ghomashchi, F., Yates, J. R., Armstrong, C. G., Paterson, A., Cohen, P., Fukunaga, R., Hunter, T., Kudo, I., Watson, S. P., and Gelb, M. H. 2000. Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. J. Biol. Chem. 275:37542-37551.

Joazeiro, C. A. P., and Hunter, T. 2000. Ubiquitination: more than two to tango. Science 289:2061-2062.

Blume-Jensen, P., and Hunter, T. 2000. Two-dimensional phosphopeptide mapping of receptor tyrosine kinases. In Protein Kinase Protocols (A. D. Reith, ed), pp. 49-65, Humana Press, New Jersey; and Methods Mol. Biol. 124:49-65, 2001.

Hunter, T. 2000. The role of tyrosine phosphorylation in cell growth and disease. The Harvey Lectures 1998-1999 94:81-119.

Sudol, M., and Hunter, T. 2000. NeW Wrinkles for an old domain. Cell 103:1001-1004.

 

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