Salk Institute

Hunter Lab


Publications 2001 - 2010

Potter, L. R., and Hunter, T. 2001. Guanylyl cyclase-linked natriuretic peptide receptors: structure and regulation. J. Biol. Chem. 276:6057-6060.

Moniakis, J., Funamoto, S., Fukuzawa, M., Meisenhelder, J., Araki, T., Abe, T., Meili, R., Hunter, T., Williams, J., and Firtel, R. A. 2001. An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway. Genes Dev. 15:687-698.

Early, A., Gamper, M., Moniakis, J., Kim, E., Hunter, T., Williams, J. G., and Firtel, R. A. 2001. Protein tyrosine phosphatase PTP1 negatively regulates Dictyostelium STATa and is required for correct cell-type proportioning. Dev. Biol. 232:233-245.

Hauck, C. R., Hunter, T., and Schlaepfer, D. 2001. The v-Src SH3 domain facilitates a cell adhesion-independent association with FAK. J. Biol. Chem. 276:17653-17662.

Lu, Z., Jiang, G., Blume-Jensen, P., and Hunter, T. 2001. EGF-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol. Cell. Biol. 21:4016-4031.

Ruffner, H., Joazeiro, C. A. P., Hemmati, D., Hunter, T., and Verma, I. M. 2001. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc. Natl. Acad. Sci. USA 98:5134-5139.

Lorén, C. E., Scully, A., Grabbe, C., Edeen, P. T., Thomas, J., McKeown, M., Hunter, T., and Palmer, R. H. 2001. Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives MAPK activation in vivo. Genes Cells 6:531-544.

Jiang, B.-H., Jiang, G., Zheng, J. Z., Lu, Z., Hunter. T., and Vogt, P. K. 2001. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Diff. 12:363-369.

Blume-Jensen, P., and Hunter, T. 2001. Oncogenic kinase signalling. Nature 411:355-365.

Woodring, P. J., Hunter, T., and Wang, J. Y. J. 2001. Inhibition of c-Abl tyrosine kinase by filamentous-actin. J. Biol. Chem. 276:27104-27110.

Tertoolen, L. G. J., Blanchetot, C., Jiang, G., Overvoorde, J., Gadella, T. W., Hunter, T., and den Hertog, J. 2001. Dimerization of Receptor Protein-Tyrosine Phosphatase alpha in living cells. BMC Cell Biology 2:8.

Huang, H.-K., Forsburg, S. L., John, U. P., O’Connell, M. J., and Hunter, T. 2001. Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe. J. Cell Sci. 114:3779-3788.

Rankin, C. A., Joazeiro, C. A. P., Floor, E., and Hunter, T. 2001. E3 ubiquitin protein ligase activity of Parkin is mediated by RING finger (TRIAD) elements. J. Biomed. Sci. 8:421-429.

Buck, M., Poli, V., Hunter, T., and Chojkier, M. 2001. C/EBP phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol. Cell 8:807-816.

Buck, M., Zhang, L., Halasz, N. A., Hunter, T., and Chojkier, M. 2001. Nuclear export of phosphorylated C/EBP mediates the inhibition of albumin expression by TNF-. EMBO J. 20:6712-6723.

Blume-Jensen, P., and Hunter, T. 2001. Kit/stem cell factor receptor in oncogenesis. In Encyclopedic Reference of Cancer (M. Schwab, ed), pp. 477-486, Springer-Verlag.

Mustelin, T., and Hunter, T. 2002. Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTP. Science STKE. 2002 (115):PE3.

Liou, Y.-C., Ryo, A., Huang, H.-K., Lu, P.-J., Bronson, R., Fujimori, F., Uchida, T., Hunter, T., and Lu, K. P. 2002. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc. Natl. Acad. Sci. USA 99:1335-1340.

Leverson, J. D., Huang, H.-K., Forsburg, S. L., and Hunter, T. 2002. The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1, and mediates chromosome segregation and cytokinesis. Mol. Biol. Cell 13:1132-1143.

Woodring, P. J., Litwack, E. D., O'Leary, D. D. M., Lucero, G. R., Wang, J. Y. J., and Hunter, T. 2002. Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J. Cell Biol. 156:879-892.

Fang, D., Elly, C., Gao, B, Fang, N., Altman, Y., Joazeiro, C., Hunter, T., Copeland, N., Jenkins, N., and Liu, Y.‑C. 2002. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nature Immunol. 3:281-287.

Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., and Montminy, M. 2002. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol. Cell. Biol. 22:2974-2983.

Lu, Z., Xu, S., Joazeiro, C., Cobb, M. H., and Hunter, T. 2002. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol. Cell 9:945-956.

Mollinari, C., Kleman, J.-P., Jiang, W., Schoehn, G., Hunter, T., and Margolis, R. L. 2002. PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J. Cell Biol. 157:1175-1186.

Hunter, T. 2002. Tyrosine phosphorylation in cell signaling and disease. Keio J. Med. 51:61-71.

Carter, N., Nakamoto, T., Hirai, H., and Hunter, T. 2002. Ephrin A1-induced cytoskeletal re-organization requires FAK and p130cas. Nature Cell Biol. 4:565-573.

Manning, G., Plowman, G. D., Hunter, T., and Sudarsanam, S. 2002. Evolution of kinase-based signaling. Trends Biochem. Sci. 27:514-520.

Manning, G., Whyte, D. B., Martinez, R., Hunter, T., and Sudarsanam, S. 2002. The protein kinase complement of the human genome. Science 298:1912-1934.

Blume-Jensen, P., and Hunter, T. 2002. Signal transduction mechanisms initiated by receptor tyrosine kinases. In Encyclopedia of Cancer (J. R. Bertino, ed), Vol. 2, pp. 213-234, Academic Press.

Blume-Jensen, P., and Hunter, T. 2002. Kinase-regulated signal transduction pathways. In Encyclopedia of Cancer (J. R. Bertino, ed), Vol. 2, pp. 553-569, Academic Press.

Uchida, T., Takamiya, M., Takahashi, M., Miyashita, H., Ikeda, H., Terada, T., Matsuo, Y., Shirouzu, M., Yokoyama, S., Fujimori, F., and Hunter, T. 2003. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem. Biol. 10:15-24.

Xia, Y., Pao, G. M., Chen, H.-W., Verma, I. M., and Hunter, T. 2003. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J. Biol. Chem. 278:5255-5263.

Verdecia, M. A., Joazeiro, C. A. P., Wells, N. J., Ferrer, J.-L., Bowman, M. E., Hunter, T., and Noel, J. P. 2003. Conformational flexibility underlies ubiquitin ligation by the WWP1 HECT domain E3 ligase. Mol. Cell 11:249-259.

Shah, O. J., Ghosh, S., and Hunter, T. 2003. Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr,Pro phosphorylation of consensus and non-consensus sites by Cdc2. J. Biol. Chem. 278:16433-16442.

O’Connell, M. J., Krien, M. J. E., and Hunter, T. 2003. Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol. 13:221-228.

Woodring, P. J., Hunter, T., and Wang, J. Y. J. 2003. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J. Cell Sci. 116:2613-2126.

Sonnenburg, E. D., Bilwes, A. M., Hunter, T., and Noel, J. P. 2003. Structure of the membrane-distal phosphatase domain of RPTP reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry 42:7904-7414.

Liou, Y.-C., Sun, A., Ryo, A., Zhou, X. Z., Yu, Z.-X., Huang, H.-K., Uchida, T., Bronson, R., Bing, G., Li, X., Hunter, T. and Lu, K. P. 2003. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424:556-561.

Hunter, T., and Manning, G. 2003. Eukaryotic kinomes: genomic cataloguing of protein kinases and their evolution. In Handbook of Cell Signaling (R.A. Bradshaw and E.A. Dennis, eds), Vol. 1, pp. 373-377, Academic Press.

Sonnenburg, E. D., Hunter, T., and Noel, J. P. 2003. Regulating receptor PTP activity. In Handbook of Cell Signaling (R. Bradshaw and E. Dennis, eds), Vol. 1, pp. 685-688, Academic Press.

Lorén, C. E., Englund, C., Grabbe, C., Hallberg, B., Hunter, T., and Palmer, R. H. 2003. A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. EMBO Reports 4:781-786.

Hunter, T. 2003. Protein phosphorylation: what does the future hold? In Life Sciences for the 21st Century (E. Keinan, I. Schechter, and M. Sela, eds), pp. 191-223, Wiley-VCH.

Lu, Z., Ghosh, S., Wang, Z., and Hunter, T. 2003. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of -catenin and enhanced tumor cell invasion. Cancer Cell 4:499-515.

Fukunaga, R., and Hunter, T. 2004. Identification of MAPK substrates by expression screening with solid-phase phosphorylation. In Methods in Molecular Biology, Vol. 250: MAP Kinase Signaling Protocols (R. Seger, ed), pp. 211-236, Humana Press.

Hunter, T., and Eckhart, W. 2004. The discovery of tyrosine phosphorylation: it’s all in the buffer! Cell S116:S35-S39.

Watanabe, N., Arai, H., Nishihara, Y., Taniguchi, M., Watanabe, N., Hunter, T., and Osada, H. 2004. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFTrCP. Proc. Natl. Acad. Sci. USA 101:4419-4424.

Shah, O. J., and Hunter, T. 2004. Critical role of T-Loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the Tuberous Sclerosis Complex. J. Biol. Chem. 279:20816-20823.

Lu, Z., and Hunter, T. 2004. Wnt-independent -catenin transactivation in tumor development. Cell Cycle 3:571-573.

Woodring, P. J., Meisenhelder, J., Johnson, S. A., Zhou, G-L., Field, J., Shah, K., Bladt, F., Pawson, T., Niki, M., Pandolfi, P. P., Wang, J. Y. J., and Hunter, T. 2004. c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J. Cell Biol. 165:493-503.

Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., and Mustelin, T. 2004. Protein tyrosine phosphatases in the human genome. Cell 117:699-711.

Caenepeel, S., Charydczak, G., Sudarsanam, S., Hunter, T., and Manning, G. 2004. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc. Natl. Acad. Sci. USA 101:11707-11712.

Shah, O. J., Wang, Z., and Hunter, T. 2004. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14:1650-1656.

Johnson, S. A., and Hunter, T. 2004. Phosphoproteomics finds its timing. Nat. Biotechnol. 9:1093-1094.

Grabbe, C., Zervas, C. G., Hunter, T., Brown, N. H., and Palmer, R. H. 2004. Focal adhesion kinase is not required for integrin function or viability in Drosophila. Development 131:5795-5805.

York, J. D., and Hunter, T. 2004. Unexpected mediators of protein phosphorylation. Science 306:2053-2055.

Johnson, S. A., and Hunter, T. 2005. Kinomics: methods for deciphering the kinome. Nature Meth. 2:17-25.

Papin, J. A., Subramaniam, S., Hunter, T., and Palsson, B. O. 2005. Reconstruction of cellular signalling networks and analysis of their properties. Nat. Rev. Mol. Cell Biol. 6:99-111.

Kamada, S., Kikkawa, U., Tsujimoto, Y., and Hunter, T. 2005. Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J. Biol. Chem. 280:857-860.

Shah, O. J., and Hunter, T. 2005. Tuberous sclerosis and insulin resistance: unlikely bedfellows reveal a TORrid affair. Cell Cycle 4:46-51.

Woodring, P. J., Hunter, T., and Wang, J. Y. J. 2005. Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. J. Biol. Chem. 280:10318-10325.

Marquardt, T., Shirasaki, R., Ghosh, S., Andrews, S. E., Carter, N., Hunter, T., and Pfaff, S. L. 2005. Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell 121:127-139.

Takagi, Y., Masuda, C. A., Chang, W.-H., Komori, H., Wang, D., Hunter, T., Joazeiro, C. A. P., and Kornberg, R. D. 2005. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Mol. Cell 18:237-243.

You, Z., Chahwan, C., Bailis, J., Hunter, T., and Russell, P. 2005. ATM activation and its recruitment to damaged DNA require binding to the C-terminus of Nbs1. Mol. Cell. Biol. 25:5363-5379.

Wang, X., Li, X., Meisenhelder, J., Hunter, T., Yoshida, S., Asami, T., and Chory, J. 2005. Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev. Cell 8:855-865.

Watanabe, N., Arai, H., Iwasaki, J.-I., Shiina, M., Ogata, K., Hunter, T., and Osada, H. 2005. Cyclin-dependent kinase (CDK) phosphorylation destabilizes Wee1A via multiple pathways. Proc. Natl. Acad. Sci. USA 102:11663-11668.

Huang, H.-K., Bailis, J. M., Gomez, E. B., Leverson, J. D., Forsburg, S. L., and Hunter, T. 2005. Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation. Mol. Cell. Biol. 25:9000-9015.

Kamada, S., Kikkawa, U., Tsujimoto, Y., and Hunter, T. 2005. A-kinase anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase-3 through an enzyme-substrate like association. Mol. Cell. Biol. 25:9469-9477.

Hunter, T., and Schulman, H. 2005. CaMKII structure – an elegant design. Cell 123:765-767.

Zhang, Y.-W., Hunter, T., and Abraham, R. T. 2006. Turning the replication checkpoint on and off. Cell Cycle 5:125-128.

Wang, Z., Qi, C., Krones, A., Woodring, P., Zhu, X., Reddy, J. K., Evans, R. M., Rosenfeld, M. G., and Hunter. T. 2006. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab. 3:111-122.

Wolff, S., Ma, H., Burch, D., Maciel, G. A., Hunter, T., and Dillin, A. 2006. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124:1039-1053.

Petersen, P., Chou, D. M., You, Z., Hunter, T., Walter. J. C., and Walter, G. 2006. Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol. Cell. Biol. 26:1997-2011.

Lu, Z., and Hunter, T. 2006. MEKK1: dual function as a protein kinase and a ubiquitin protein ligase. In Intracellular Proteolysis (R. J. Mayer, A. Ciechanover, and M. Rechsteiner, eds), pp. 79-88, Wiley-VCH.

Shah, O. J., and Hunter, T. 2006. Turnover of the active fraction of IRS1 involves Raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol. Cell. Biol. 26:6425-6434.

Joazeiro, C. A. P., Anderson, K. C., and Hunter, T. 2006. Proteasome inhibitor drugs on the rise. Cancer Res. 66:7840-7842.

Ghosh, S., Tergaonkar, V., Rothlin, C. V., Correa, R. C., Bottero, V., Bist, P., Verma, I. M., and Hunter, T. 2006. Essential role of Tuberous Sclerosis Complex genes TSC1/2 in NF-B activation and cell survival. Cancer Cell 10:215-226.

Hunter, T. and Simon, J. 2007. A not so brief history of the Oncogene Meeting and its cartoons. Oncogene 26:1260-1267.

Xia, Y., Wang, J., Xu, S., Johnson, G. L., Hunter, T., and Lu, Z. 2007. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol. Cell. Biol. 27:510-517.

Han, E. K., Leverson, J. D., McGonigal, T., Shah, O. J., Woods, K. W., Hunter, T., Giranda, V. L., and Luo, Y. 2007. Akt inhibitor A-443654 induces rapid Akt Ser-473 feedback phosphorylation independent of mTORC1 inhibition. Oncogene 26:5655-5661.

Xia, Y., Wang, Y., Liu, T.-J., Yung, W. K. A., Hunter, T., and Lu, Z. 2007. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol. Cell 25:219-232.

Fang, D., Hawke, D., Zheng, Y., Xia, Y., Meisenhelder, J., Nika, H., Mills, G. B., Kobayashi, R., Hunter, T., and Lu, Z. 2007. Phosphorylation of b-catenin by AKT promotes b-catenin transcriptional activity. J. Biol. Chem. 282:11221-11229.

Johnson, S. A., You, Z., and Hunter, T. 2007. Monitoring ATM kinase activity in living cells. DNA Repair 6:1277-1284.

Bozulic, L., Morin, P. Jr., Hunter, T., and Hemmings, B.A. 2007. Meeting Report: Targeting the kinome – 20 years of tyrosine kinase inhibitor research in Basel. STKE 2007, pe8.

Zhang, Y., Daum, S., Wildemann, D., Zhou, X. Z., Verdecia, M. A., Bowman, M. E., Lucke, C., Hunter, T., Lu, K. P., Fischer, G., and Noel, J. P. 2007. Structural basis for high affinity peptide based inhibition of human Pin1. ACS Chem. Biol. 2:320-328.

Hunter, T. 2007. Treatment for chronic myelogenous leukemia: the long road to imatinib. J. Clin. Invest. 117:2036-2043.

Sun, H., Leverson, J. D., and Hunter, T. 2007. Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J. 26:4102-4012.

You, Z., Bailis, J. M., Johnson, S. A., Dilworth, S. M., and Hunter, T. 2007. Rapid activation of ATM on DNA flanking double-strand breaks. Nat. Cell Biol. 9:1311-1318.

Pearson, G. W., and Hunter, T. 2007. Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells. J. Cell Biol. 179:1555-1567.

Hunter, T. 2007. The age of crosstalk: phosphorylation, ubiquitination and beyond. Mol. Cell 28:730-738.

Ghosh, S., Marquardt, T., Thaler, J. P., Carter, N., Andrews, S. E., Pfaff, S. L., and Hunter, T. 2008. Instructive role of aPKCz subcellular localization in the assembly of adherens junctions in neural progenitors. Proc. Natl. Acad. Sci. USA 105:335-340.

Bailis, J. M., Luche, D. D., Hunter, T., and Forsburg, S. L. 2008. Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote S-phase genome stability. Mol. Cell. Biol. 28:1724-1738.

Hashimoto, T., Yamauchi, L., Hunter, T., Kikkawa, U., and Kamada, S. 2008. Possible involvement of caspase-7 in cell cycle progression at mitosis. Genes Cells 13:609-621.

Hunter, T., and Sun, H. 2008. Crosstalk between the SUMO and ubiquitin pathways. In Ernst Schering Foundation Symposium on “The Ubiquitin System in Health and Disease”, pp. 1-16.

Copp, J., Manning, G., and Hunter, T. 2009. TORC–specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res. 69:1821-1827.

Smith, J. J., Putta, S., Zhu, W., Pao, G. M., Verma, I. M., Hunter, T., Bryant, S. V., Gardiner, D. M., Harkins, T. T., and Voss, S. R. 2009. Genic regions of a large salamander genome contain long introns and novel genes. BMC Genomics 10:19.

Monaghan, J. R., Epp, L. G., Putta, S., Page, R. B., Walker, J. A., Beachy, C. K., Zhu, W., Pao, G. M., Verma, I. M., Hunter, T., Bryant, S. V., Gardiner, D. M., Harkins, T. T., and Voss, S. R. 2009. Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration. BMC Biol. 7:1.

Lu, Z., and Hunter, T. 2009. Degradation of activated protein kinases by ubiquitination. Annu. Rev. Biochem. 78:435-475.

Carrano, A. C., Liu, Z., Dillin, A., and Hunter, T. 2009. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460:396-399.

Joazeiro, C. A. P., and Hunter, T. 2009. RING finger proteins as E3 ubiquitin ligases. In Protein Discovery Technologies: Principles (R. Pasqualini and W. Arap, eds), pp.203-213, CRC Press.

Pearson, G. W., and Hunter, T. 2009. PI-3 kinase activity is necessary for ERK1/2 induced disruption of mammary epithelial architecture. Breast Cancer Res. 11:R29.

Hunter, T. 2009. Tyrosine phosphorylation: thirty years and counting. Curr. Opin. Cell Biol. 21:140-146.

Zhang. Y.-W., Brognard, J., Coughlin, C., You, Z., Dolled-Filhart, M., Aslanian, A., Manning, G., Abraham, R. T., and Hunter, T. 2009. The F-box protein Fbx6 regulates stability of Chk1 and cellular sensitivity to replication stress. Mol. Cell 35:442-453.

Sun, H., and Hunter, T. 2009. Crosstalk between the ubiquitin and SUMO pathways. In The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology (M. Di Napoli and C. Wojcik, eds), Nova Publishers, pp. 33-52.

Malumbres, M., Harlow, E., Hunt, T., Hunter, T., Lahti, J. M., Manning, G., Morgan, D. O., Tsai, L.-H., and Wolgemuth, D. J. 2009. Cyclin-dependent kinases: a family portrait. Nat. Cell Biol. 11:1275-1276.

Manning, G., and Hunter. T. 2009. Eukaryotic kinomes: genomics and evolution of protein kinases. In Handbook of Cell Signaling, Second Edition (R.A. Bradshaw and E.A. Dennis, eds), Vol. 1, pp. 393-397, Elsevier Press.

You, Z., Shi, L. Z., Zhu, Q., Wu, P., Zhang, Y. W., Basilio, A., Tonnu, N., Verma, I. M., Berns, M. W., and Hunter, T. 2009. CtIP links DNA double-strand break sensing and resection. Mol. Cell 36:954-969.

Hunter, T, and Marais, R. 2010. Genetic and cellular mechanisms of oncogenesis: Editorial overview. Curr. Opin. Genet. Develop. 20:1-3.

López-Otín, C., and Hunter, T. 2010. The regulatory crosstalk between kinases and proteases in cancer. Nat. Rev. Cancer 10:278-292.

Lu, Z., and Hunter, T. 2010. Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1, and p57Kip2 CDK inhibitors. Cell Cycle 9:2342-2352.

Liew, C. W., Sun, H., Hunter, T., and Day, C. L. 2010. RING domain dimerization is essential for RNF4 function. Biochem. J. 431:23-29.

Yoon, Y.-S., Lee, M.-W., Ryu, D., Kim, J. H., Ma, M., Seo, W.-Y., Kim, Y.-N., Kim, S. S., Lee, C. H., Hunter, T., Choi, C. S., Montminy, M. R., and Koo, S.-H. 2010. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Proc. Natl. Acad. Sci. USA 107:17704-17709.

Olson, B. J. S. C., Oberholzer, M., Li, Y., Zones, J. M., Kohli, H. S., Bisova, K., Fang, S. C., Meisenhelder, J., Hunter, T. and Umen, J. G. 2010. Regulation of the cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex. Plant Cell 22:3331-3347.

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